Southampton will be without Jan Bednarek, Aaron Ramsdale, Taylor Harwood-Bellis, Tyler Dibling, Flynn Downes and Adam Lallana for this crucial match. These absences pose a significant challenge to the team's lineup and tactics.
The midfield especially becomes a tricky area with Joe Aribo available but Lesley Ugochukwu unable to play against his parent club. This leaves Russell Martin with some tough decisions to make.
Yukinari Sugawara and Jack Stephens are likely to play key roles. Jack Stephens has to start, and Charlie Taylor may come in at left-back or at centre-back with Kyle Walker-Peters, allowing Charlie Taylor to play in a different position.
Going back to last season, Adam Armstrong popped back into midfield with success for several games. But facing Chelsea is a different level, and Martin needs to find the right combination.
The absence of these players will undoubtedly have an impact on Southampton's performance against Chelsea. It will test Martin's tactical acumen and the team's ability to adapt.
With such a crucial game at stake, every decision and every player on the pitch will be crucial in determining the outcome of the match.