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What is Entresto?

Entresto is a prescription medication used to treat heart failure, specifically in patients with chronic heart failure with reduced ejection fraction (HFrEF). It combines two active ingredients: sacubitril, which helps reduce blood pressure and decrease strain on the heart, and valsartan, an angiotensin II receptor blocker that relaxes blood vessels. Together, these components work to improve heart function, reduce hospitalizations, and increase the chances of survival for heart failure patients.

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How Does Entresto Work?

Entresto works by blocking the enzyme that degrades natriuretic peptides, which are natural hormones that help reduce fluid retention and lower blood pressure. This mechanism helps the heart pump more effectively by reducing the stress on the heart muscle and preventing fluid buildup in the lungs and other tissues. By also blocking angiotensin II, Entresto prevents blood vessels from narrowing, further lowering blood pressure and easing the workload on the heart.

Benefits of Entresto

The benefits of Entresto are significant for those living with chronic heart failure. Studies have shown that Entresto can reduce the risk of cardiovascular death and hospitalization by as much as 20% compared to traditional heart failure treatments. In addition, patients often experience improvements in their overall quality of life, with reduced symptoms like shortness of breath and fatigue. Entresto's dual action makes it more effective than standard medications in helping the heart function efficiently.

Potential Side Effects

As with any medication, Entresto has potential side effects. The most common include low blood pressure, elevated potassium levels, and kidney function changes. Some patients may experience dizziness or a persistent cough. In rare cases, Entresto can lead to serious complications like angioedema (swelling of the face, lips, or throat), which requires immediate medical attention. It’s important for patients to have regular check-ups to monitor for side effects and adjust dosage if necessary.

Who Should Use Entresto?

Entresto is prescribed for adults with heart failure who have reduced ejection fraction, a condition where the heart’s ability to pump blood is weaker than normal. It is particularly useful for patients who are not responding well to other heart failure medications. However, Entresto is not recommended for those with certain conditions, such as severe kidney or liver problems, or pregnant women. A healthcare provider will evaluate whether Entresto is the right choice based on the patient’s medical history and overall health.

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