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If you or a loved one has recently been diagnosed with a blood cancer, you may be feeling overwhelmed and scared. The good news is that advancements in medical research and technology have led to the development of new treatments, such as zanubrutinib. This targeted therapy has shown promising results in treating various types of blood cancers. In this article, we will explore what zanubrutinib is, how it works, and its effectiveness as a treatment option.

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What is Zanubrutinib?

Zanubrutinib, also known as Brukinsa, is a type of medication called a kinase inhibitor. It specifically targets and blocks a protein called Bruton’s tyrosine kinase (BTK). This protein plays a crucial role in the development and survival of certain types of blood cells, which can lead to the growth and progression of blood cancers like chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL).

How Does it Work?

Zanubrutinib works by binding to and inhibiting the function of the BTK protein. This blocks certain signaling pathways that are responsible for the growth and proliferation of cancer cells. This helps to slow down or stop the growth of cancer cells, ultimately preventing them from spreading to other parts of the body.

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Effectiveness of Zanubrutinib

Zanubrutinib was approved by the U.S. Food and Drug Administration (FDA) in 2019 for the treatment of MCL, a type of non-Hodgkin lymphoma. It has since been approved for the treatment of CLL in 2020. Clinical trials have shown that zanubrutinib is highly effective in treating these types of cancers. In fact, in one study, it was found to be more effective than another commonly used treatment for MCL.

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Side Effects

Like any medication, zanubrutinib can cause side effects. However, the most common side effects reported in clinical trials were mild, including diarrhea, nausea, fatigue, and headache. Some patients may also experience more serious side effects such as low blood cell counts, increased risk of infection, and bleeding problems. It is important to discuss any side effects with your doctor and report any new or concerning symptoms.

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Who Can Take Zanubrutinib?

Zanubrutinib is approved for use in adults with MCL who have received at least one prior treatment and in adults with CLL who have received at least one prior therapy or are not able to receive other treatments. However, it is always important to consult with your doctor to determine if zanubrutinib is the right treatment option for you based on your individual medical history and current condition.

Other Important Information

Zanubrutinib is taken orally in the form of a capsule and is typically taken once or twice a day depending on your specific treatment plan. It is important to follow your doctor’s instructions and take the medication as prescribed. Also, be sure to inform your doctor of any other medications or supplements you are taking, as they may interact with zanubrutinib. If you miss a dose of zanubrutinib, take it as soon as possible, unless it is close to your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. It is also important to note that zanubrutinib may cause harm to an unborn baby, so it is not recommended for use during pregnancy. It is important to use effective birth control while taking this medication and for a certain period of time after stopping the medication.

In Conclusion

Zanubrutinib is a promising new treatment option for blood cancers like MCL and CLL. It works by targeting and inhibiting a specific protein involved in the growth and development of cancer cells. While it may cause some side effects, they are often mild and manageable. If you or someone you know is looking for a targeted therapy option for blood cancer, speak with your doctor about zanubrutinib and whether it may be a suitable treatment option for you.