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Breast cancer is one of the most common forms of cancer in women, affecting millions of lives each year. Thanks to advancements in medical research, new treatments are constantly being developed to combat this disease. One of the most promising treatments in recent years is Kisqali, a medication approved by the FDA in 2017 for the treatment of hormone receptor-positive (HR+), HER2-advanced or metastatic breast cancer.

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What is Kisqali?

Kisqali, also known by its generic name ribociclib, is a targeted therapy that works by inhibiting the growth of cancer cells. It is classified as a CDK4/6 inhibitor, which means it blocks the activity of certain enzymes that promote cell division and growth. This targeted approach makes it more effective and less toxic than traditional chemotherapy, which can damage healthy cells in addition to cancer cells.

How does Kisqali work?

Kisqali is typically used in combination with other hormone therapy medications, such as letrozole or anastrozole. These medications work by blocking the production of estrogen, a hormone that can fuel the growth of hormone receptor-positive breast cancer cells. By adding Kisqali to the mix, it can further prevent the growth and spread of cancer cells by targeting the CDK4/6 enzymes. This combination therapy has shown remarkable results in clinical trials, with many patients experiencing significant shrinkage of their tumors.

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Who can benefit from Kisqali?

Kisqali is specifically approved for use in postmenopausal women with HR+, HER2-advanced or metastatic breast cancer. This type of breast cancer accounts for about two-thirds of all breast cancer cases. Kisqali can be used as a first-line treatment in combination with hormone therapy, or as a second-line treatment if the cancer has progressed after previous hormone therapy. It is not suitable for use in premenopausal women or men.

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How is Kisqali taken?

Kisqali is taken in pill form once a day for 21 days, followed by a 7-day break. This 28-day cycle is repeated as long as the treatment is beneficial and tolerated by the patient. It is important to take Kisqali at the same time each day, preferably with food. It is also crucial to follow the dosage instructions and any other guidelines provided by the prescribing doctor.

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What are the side effects of Kisqali?

Like any medication, Kisqali can cause side effects. The most common side effects reported in clinical trials were low white blood cell count, nausea, fatigue, diarrhea, hair thinning or loss, decreased appetite, and headache. However, these side effects were generally mild and manageable. In rare cases, Kisqali can cause more serious side effects, such as severe infections, liver problems, and heart rhythm abnormalities. Patients should discuss any concerns or side effects with their doctor.

Is Kisqali covered by insurance?

Kisqali is approved by the FDA and is available by prescription from a doctor. Like most cancer treatments, it can be expensive. However, many insurance plans will cover the cost of Kisqali, with the exception of copay or coinsurance amounts. Patients may also be eligible for financial assistance programs offered by the manufacturer or other organizations.

Final Thoughts

Kisqali has been a game-changer in the treatment of HR+, HER2-advanced or metastatic breast cancer. It has shown impressive results in clinical trials and has provided hope for many women facing this devastating disease. If you or a loved one is struggling with hormone receptor-positive breast cancer, talk to your doctor about whether Kisqali may be a suitable treatment option.

• Targeted therapy that blocks the activity of certain enzymes in cancer cells
• Approved for use in postmenopausal women with HR+, HER2-advanced or metastatic breast cancer
• Typically used in combination with other hormone therapy medications
• Taken in pill form once a day for 21 days, followed by a 7-day break
• Common side effects include low white blood cell count, nausea, and fatigue